Hepatology Calculators

by Oren Fix, MD

Hepatology Calculators
by Oren Fix, MD

Oren Fix is a transplant hepatologist and clinical informaticist in Chapel Hill, NC.


Values entered in a calculator are copied into corresponding values in other calculators.

The result of the BMI calculator is copied into the BMI field of the NAFLD Fibrosis Score calculator.


Kim WR, Biggins SW, Kremers WK, et al. Hyponatremia and mortality among patients on the liver-transplant waiting list. N Engl J Med 2008;359(10):1018-26. PMID: 18768945 Sharma P, Schaubel DE, Goodrich NP, et al. Serum sodium and survival benefit of liver transplantation. Liver Transpl 2015;21(3):308-13. PMID: 25504743 Biggins SW. Use of serum sodium for liver transplant graft allocation: a decade in the making, now is it ready for primetime? Liver Transpl 2015;21(3):279-81. PMID: 25641769


Keys A, Fidanza F, Karvonen MJ, et al. Indices of relative weight and obesity. J Chronic Dis 1972;25(6):329-43. PMID: 4650929


Child CG, Turcotte JG. Surgery and portal hypertension. In: The liver and portal hypertension. Edited by CG Child. Philadelphia: Saunders 1964:50-64. PMID: 4950264 Pugh RN, Murray-Lyon IM, Dawson JL, et al. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973;60(8):646-9. PMID: 4541913

Maddrey's Discriminant Function:

Maddrey WC, Boitnott JK, Bedine MS, et al. Corticosteroid therapy of alcoholic hepatitis. Gastroenterology 1978;75(2):193-9. PMID: 352788

Lille Model:

Louvet A, Naveau S, Abdelnour M, et al. The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids. Hepatology 2007;45(6):1348-54. PMID: 17518367

APRI (AST-Platelet Ratio Index):

Wai CT, Greenson JK, Fontana RJ, et al. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C. Hepatology 2003;38(2):518-26. PMID: 12883497


Sterling RK, Lissen E, Clumeck N, et al. Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection. Hepatology 2006;43(6):1317-25. PMID: 16729309

NAFLD Fibrosis Score:

Angulo P, Hui JM, Marchesini G, et al. The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD. Hepatology 2007 Apr;45(4):846-54. PMID: 17393509

NAFLD Activity Score:

Kleiner DE, Brunt EM, Van Natta M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005;41(6):1313-21. PMID: 15915461

Predicting Cancer Recurrence Score (PCRS):

Chan EY, Larson AM, Fix OK, et al. Identifying risk for recurrent hepatocellular carcinoma after liver transplantation: implications for surveillance studies and new adjuvant therapies. Liver Transpl 2008 Jul;14(7):956-65. PMID: 18581511

Risk Estimation of Tumor Recurrence After Transplant (RETREAT):

Mehta N, Heimbach J, Harnois DM, et al. Validation of a Risk Estimation of Tumor Recurrence After Transplant (RETREAT) score for hepatocellular carcinoma recurrence after liver transplant. JAMA Oncol 2017;3(4):493-500. PMID: 27838698 Mehta N, Dodge JL, Roberts JP, et al. Validation of the prognostic power of the RETREAT score for hepatocellular carcinoma recurrence using the UNOS database. Am J Transplant 2018 May;18(5)1206-1213. PMID: 29068145 Verna EC, Patel YA, Aggarwal A, et al. Liver transplantation for hepatocellular carcinoma: management after the transplant. Am J Transplant. 2020;20(2):333-347. PMID: 31710773 Mehta N, Frenette C, Tabrizian P, et al. Downstaging Outcomes for Hepatocellular Carcinoma: Results from the Multicenter Evaluation of Reduction in Tumor Size before Liver Transplantation (MERITS-LT) Consortium. Gastroenterol. 2021;161:1502-1512. PMID: 34331914

© Oren Fix. All rights reserved.

MELD-Na Calculator


*2 or more dialysis treatments within the prior week
or 24 hours of CVVHD within the prior week


BMI Calculator

Child-Turcotte-Pugh Calculator

Maddrey's Discriminant Function Calculator

Lille Model Calculator

APRI Calculator

FIB4 Calculator

NAFLD Fibrosis Score Calculator

IFG / Diabetes

*impaired fasting glucose

NAFLD Activity Score (NAS) Calculator

Predicting Cancer Recurrence Score (PCRS) Calculator

Largest tumor diameter >4.5 cm?
Tumor in both lobes?
Macrovascular invasion?
Well-differentiated tumor grade?

RETREAT Calculator

Microvascular invasion on explant pathology?

Do not count completely necrotic lesions

Only measure the diameter of viable tumor