Hepatology Calculators

Hepatology Calculators
by Oren Fix, MD

Oren Fix is a transplant hepatologist and clinical informaticist in Chapel Hill, NC.

Tips:

Values entered in a calculator are copied into corresponding values in other calculators.

The result of the BMI calculator is copied into the BMI field of the NAFLD Fibrosis Score calculator.

MELD-Na:

Kim WR, Biggins SW, Kremers WK, et al. Hyponatremia and mortality among patients on the liver-transplant waiting list. N Engl J Med 2008;359(10):1018-26. PMID: 18768945 Sharma P, Schaubel DE, Goodrich NP, et al. Serum sodium and survival benefit of liver transplantation. Liver Transpl 2015;21(3):308-13. PMID: 25504743 Biggins SW. Use of serum sodium for liver transplant graft allocation: a decade in the making, now is it ready for primetime? Liver Transpl 2015;21(3):279-81. PMID: 25641769

BMI:

Keys A, Fidanza F, Karvonen MJ, et al. Indices of relative weight and obesity. J Chronic Dis 1972;25(6):329-43. PMID: 4650929

Child-Turcotte-Pugh:

Child CG, Turcotte JG. Surgery and portal hypertension. In: The liver and portal hypertension. Edited by CG Child. Philadelphia: Saunders 1964:50-64. PMID: 4950264 Pugh RN, Murray-Lyon IM, Dawson JL, et al. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973;60(8):646-9. PMID: 4541913

Maddrey's Discriminant Function:

Maddrey WC, Boitnott JK, Bedine MS, et al. Corticosteroid therapy of alcoholic hepatitis. Gastroenterology 1978;75(2):193-9. PMID: 352788

Lille Model:

Louvet A, Naveau S, Abdelnour M, et al. The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids. Hepatology 2007;45(6):1348-54. PMID: 17518367

APRI (AST-Platelet Ratio Index):

Wai CT, Greenson JK, Fontana RJ, et al. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C. Hepatology 2003;38(2):518-26. PMID: 12883497

FIB4:

Sterling RK, Lissen E, Clumeck N, et al. Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection. Hepatology 2006;43(6):1317-25. PMID: 16729309

NAFLD Fibrosis Score:

Angulo P, Hui JM, Marchesini G, et al. The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD. Hepatology 2007 Apr;45(4):846-54. PMID: 17393509

NAFLD Activity Score:

Kleiner DE, Brunt EM, Van Natta M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005;41(6):1313-21. PMID: 15915461

Predicting Cancer Recurrence Score (PCRS):

Chan EY, Larson AM, Fix OK, et al. Identifying risk for recurrent hepatocellular carcinoma after liver transplantation: implications for surveillance studies and new adjuvant therapies. Liver Transpl 2008 Jul;14(7):956-65. PMID: 18581511

Risk Estimation of Tumor Recurrence After Transplant (RETREAT):

Mehta N, Heimbach J, Harnois DM, et al. Validation of a Risk Estimation of Tumor Recurrence After Transplant (RETREAT) score for hepatocellular carcinoma recurrence after liver transplant. JAMA Oncol 2017;3(4):493-500. PMID: 27838698 Mehta N, Dodge JL, Roberts JP, et al. Validation of the prognostic power of the RETREAT score for hepatocellular carcinoma recurrence using the UNOS database. Am J Transplant 2018 May;18(5)1206-1213. PMID: 29068145 Verna EC, Patel YA, Aggarwal A, et al. Liver transplantation for hepatocellular carcinoma: management after the transplant. Am J Transplant. 2020;20(2):333-347. PMID: 31710773 Mehta N, Frenette C, Tabrizian P, et al. Downstaging Outcomes for Hepatocellular Carcinoma: Results from the Multicenter Evaluation of Reduction in Tumor Size before Liver Transplantation (MERITS-LT) Consortium. Gastroenterol. 2021;161:1502-1512. PMID: 34331914

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